QUÁ TRÌNH ĐÀO TẠO

QUÁ TRÌNH CÔNG TÁC

GIẢNG DẠY

HƯỚNG NGHIÊN CỨU

• Nghiên thành phần hóa học và hoạt tính sinh học các cấy thuốc Việt Nam
• Nghiên cứu bán tổng hợp các hợp chất mới hướng đích tác dụng enzym HDAC, hoạt tính kháng ung thư, kháng khuẩn, kháng viêm từ artemisnin, quinazoline, coumarin and gossypol.
• Nghiên cứu các hệ vận chuyển thuốc mới: microfluidic and electrospinning.

CHỦ TRÌ VÀ THAM GIA CÁC ĐỀ TÀI NGHIÊN CỨU

CÁC CÔNG TRÌNH KHOA HỌC

• Trần Khắc Vũ, Nguyễn Lê Anh, Đỗ Thị Thảo '' Dẫn xuất Zudovudin dùng làm chất chống ung thư và quy trình tổng hợp dẫn xuất này'' Bằng độc quyền giải pháp hữu ích: Số đơn: 2-2017-00162 (63081/QĐ-SHTT ngày 12.09.2017)
• Trần Khắc Vũ, Nguyễn Lê Anh, Đỗ Thị Thảo ''Dẫn xuất Zudovudin dùng làm chất chống ung thư và quy trình tổng hợp dẫn xuất này'' Bằng Độc quyền sáng chế: Số đơn: 1-2013-03866 (63110/QĐ-SHTT ngày 12.09.2017).
• Trần Khắc Vũ '' Hợp chất axit hydroxamic chứa khung quinazolinon có hoạt tính chống ung thư và quy trình tổng hợp các hợp chất này”, Bằng độc quyền sáng chế, mã số 32971, cấp ngày, 07/04/2022.
• Trần Khắc Vũ, Đỗ Thị Thảo '' Các axit hydroxamic trên cơ sở hệ liên hợp quinazolinon có hoạt tính chống ung thư và quy trình tổng hợp các hợp chất này'', Bằng độc quyền giải pháp hữu ích, mã số 3032, cấp ngày 25/11/2022.

• Nguyen Quang Khai, Tran Khac Vu, Coumarin-derived Hydroxamic Acids as Histone Deacetylase Inhibitors: A Review of Anti-cancer Activities, Anti-cancer Agents in Medicinal Chemistry, 2023, DOI: 10.2174/0118715206272112231102063919
• La Quy Luong, Tran Khac Vu, Coumarin-Derived Mannich Bases: A Review of Biological Activities, Letters in Organic Chemistry, 2023, DOI: 10.2174/1570178620666230622113356
• Duc Anh Le, Ngoc Hung Truong, Van Dung Vu, Thanh Huyen Doan, Minh Tri Le, Thi Huong Nguyen, Manh Cuong Nguyen, Huu Nghi Do, Duc Bao Ninh, Phong Le, Thi Phuong Thao Nguyen, Van Chinh Luu, Khac Vu Tran,  Design, Synthesis, and Biological Activity Evaluation of Novel AZT and Adenosine-Derived 1, 2, 3-Triazole, Hindawi Journal of Chemistry, 2023, Article ID 1605316 | https://doi.org/10.1155/2023/1605316
• Trinh Thi Thuy, Nguyen Thi Thuy Linh, Hoa Nguyen Thi Thu, Ba Thi Cham,Tran Duc Quan, Thi Thao Do, Nguyen Thi Hoang Anh, Pham Minh Quan, Domenico V. Delfino, Tran Khac Vu, Novel trans-caffeate hydrazide derivatives: synthesis, inhibition of nitric oxide (NO) production and molecular docking studies, Natural Product Chemistry, 2023, https://doi.org/10.1080/14786419.2023.2272020
• Nguyen Van Minh, Nguyen Thi Phuong Thao, Nguyen Pham Duy Linh & Tran Khac Vu, New quinazolinone-based Mannich bases: Synthesis and in vitro cytotoxic evaluation, Indian Journal of Chemistry, 2023, 62, 244-250. DOI: 10.56042/ijc.v62i3.71995.
• Anh Tuan Phung, Nguyen P. Duy Linh, Tran Khac Vu, and Nguyen Thanh Liem, A Study Of UV-curable Offset Ink Emulsified With An Alternative Isopropyl Alcohol-free Fountain Solution, Journal of Applied Science and Engineering, 2023, 27, 1867-1876.
• Minh Duc Nguyen, Khac Vu Tran, Cu Trung Dang, Gyu Man Kim, Trung Dung Dang, Hong Duc Ta, Ich Long Ngo, Generalized correlation for predicting the droplet size in a microfluidic flow-focusing device under the effect of surfactant, Physics of Fluids, 2022, https://doi.org/10.1063/5.0084872
• Luu Xuan Hieu, Tran Thi Hong Ha, Hoang Kim Chi, Tran Khac Vu, Pham Van Chung, Truong Ngoc Hung, and Luu Van Chinh, Novel Derivatives Based on Zerumbone Scaffold as Potential Anticancer Inhibitors, Letters in Organic Chemistry, 2022, 19, 1062-1069.
• Tran Khac Vu, Bach Xuan Nguyen, Linh Nguyen Pham Duy, Thuc Bao Nguyen Truong, Anh Tuan Phung, Nguyen Thi Bich Phuong, Tran Thi Hai Van and Thi Xuan Vu, Design, Synthesis and In vitro Cytotoxic Evaluation of Novel Hybrids of Artemisinin and Quinazolinone, Letters in Organic Chemistry, 2022, 19, 7, 558-569.
• Dao Viet Hung 1 and Tran Khac Vu, Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d] pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1), Hindawi Journal of Chemistry, 2021, Article ID 7526347, https://doi.org/10.1155/2021/7526347
• Long Hoang Ngo, Thi Hai Yen Nguyen, Vu Khac Tran, Vu Van Doan, Minh Van Nguyen, Hieu Trung Bui, Screening antibacterilal activity of Vietnamese plant extracts against human pathogenic bacteria, Asian J Pharm Clin Res, 2021, 14, 62-65.
• Ta Hong Duc, Tran Khac Vu, Cu-Trung Dang, Van Hoang Nguyen, D. Duc La, Gyu Man Kim, S. Woong Chang, Xuan-Thanh Bui, Trung-Dung Dang, D. Duc Nguyen, Synthesis and application of hydrogel calcium alginate microparticles as a biomaterial to remove heavy metals from aqueous media, Environmental Technology & Innovation, 2021, 101400. https://doi.org/10.1016/j.eti.2021.101400.
• Tran Khac Vu, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh, Pham-The Hai, Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation, Medicinal Chemistry, 2021,17, 732-749.
• Vu Van Vu and Tran Khac Vu, Synthesis of New Zerumbone Hydrazones and Their In vitro Anticancer Activity, Current Bioactive Compounds, 2021, 17, 331-338.
• Amely Täufer, Dirk Michalik, Vu Dinh Tien, Tran Khac Vu, Markus Vogt, Angela Köckritz, Hydrogenation of gossypol catalyzed by supported noble metals, Tetrahedron Letters, 2020, 61, 152630.
• Vu Binh Duong, Pham Van Hien, Tran Thai Ngoc,  Phan Dinh Chau, Tran Khac Vu, A Simple Synthesis of the Anticancer Drug Altretamine, Letters in Organic Chemistry, 2020, 17 (8) 628-630.
• Huy, Luu D. Diep, Nguyen T.; Vu, Tran K.; Savinova, Tatiana S.; Donova, Marina V. An Efficient Procedure for the Synthesis of 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, Combinatorial Chemistry & High Throughput Screening, 2020, 23, 225-231.
• Vu Tien Chinh, Pham Thanh Loan, Vu Xuan Duong, Tran Khac Vu and Luu Van Chinh, Synthesis of New Zerumbone Derivatives and Their In vitro Anti-cancer Activity, Chiang Mai J. Sci, 2020; 47(1) : 181-194.
• Nguyen V. Minh, Nguyen T. Thanh, Hoang T. Lien, Dinh T.P. Anh, Ho D. Cuong, Nguyen H. Nam, Pham T. Hai, Le Minh-Ngoc, Huong Le-Thi-Thu, Luu V. Chinh and Tran K. Vu, Design, Synthesis and Biological Evaluation of Novel N-hydroxyheptanamides Incorporating 6-hydroxy-2-methylquinazolin-4(3H)-ones as Histone Deacetylase Inhibitors and Cytotoxic Agents, Anti-Cancer Agents in Medicinal Chemistry, 2019, 19, 1543-1557.
• Vu Dinh Tien, Vu Van Vu and Tran Khac Vu, A New Synthetic Route for Preparation of Enantiomers of Gossypol and Apogossypol from Racemic Gossypol, Asian Journal of Chemistry, 2019, 31, 105-108.
• Dan Trong Nguyen, Giang Nguyen Truong, Truong Van Vuong, Tai Nguyen Van,  Cuong Nguyen Manh, Cuong To Dao, Thuy Dinh Thi Thuy, Chinh Luu Van, Vu Tran Khac, Synthesis of new indirubin derivatives and their in vitro anticancer activity, Chemical Papers, 2018, https://doi.org/10.1007/s11696-018-0659-4.
• Thinh Van Nguyen, Hien Van Pham, Duong Binh Vu, Anh Tuan Dang,Vu Khac Tran, Microwave Method for the Synthesis of Amantadine Hydrochloride, Chiang Mai J. Sci. 2018; 45(6) : 2454-2458, http://epg.science.cmu.ac.th/ejournal.
• Trinh Thi Nhung, Nguyen Thi Thanha, Vu Dinh Tien, Luu Duc Huy & Tran Khac Vu, D-Tryptophan methyl ester as an effective reagent for the preparation of optically active (−)-gossypol, Indian Journal of Chemistry, 2018, 722-726.
• Doan Thanh Hieu, Duong Tien Anh, Nguyen Minh Tuan, Pham-The Hai, Le-Thi-Thu Huong, Jisung Kim, Jong Soon Kang, Tran Khac Vu, Phan Thi Phuong Dung, Sang-Bae Han, Nguyen-Hai Nam, Nguyen-Dang Hoa, Design, synthesis and evaluation of novel N-hydroxybenzamides/Nhydroxypropenamides incorporating quinazolin-4(3H)-ones as histone deacetylase inhibitors and antitumor agents, Bioorganic Chemistry, 2018, 76, 258–267.
• Vu Van Vu, Trinh Thi Nhung, Nguyen Thi Thanh, Luu Van Chinh, Vu Dinh Tien, Vu Thu Thuy, Do Thi Thao, Nguyen Hai Nam, Angela Koeckritz, and Tran Khac Vu, Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones, Hindawi Journal of Chemistry, 2017, Article ID 3687182.
• Thuy Thu Vu, Hun Kim, Vu Khac Tran, Hoang Dinh Vu, Jae Woo Han, Yong Ho Choi, Kyoung Soo Jang, Gyung Ja Choi, Jin-Cheol Kim, Antibacterial activity of tannins isolated from Sapium baccatum extract and use for control of tomato bacterial wilt, PLOS ONE, 2017, | https://doi.org/10.1371/journal.pone.0181499.
• Luu Van Chinh, Le Duc Anh, Nguyen Thi Nga, Nguyen Thi Hai Ly, Vu Thi Ha, Tran Quoc Toan, Nguyen Manh Cuong and Tran Khac Vu, Synthesis and In Vitro Cytotoxic Evaluation of Novel Murrayafoline A Derived β-Amino Alcohols, Letters in Organic Chemistry, 2017, 14, 603-611.
• Tran Thi Lan Huong, Le Van Cuong, Pham Thu Huong, Tran Phuong Thao, Le-Thi-Thu Huong, Phan Thi Phuong Dung, Dao Thi Kim Oanh,  Nguyen Thi Mai Huong, Hoang-Van Quan, Tran Khac Vu, Jisung Kim, Jae-Hee Lee, Sang-Bae Han, Pham-The Hai, Nguyen-Hai Nam, Exploration of some indole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents, Chem. Paper, 2017,  DOI 10.1007/s11696-017-0172-1.
• Thi Mai Dung, Phan Thi Phuong Dung, Dao Thi Kim Oanh,  Tran Khac Vu, Hyunggu Hahn, Byung Woo Han, Minji Pyo, Young Guk Kim, Sang-Bae Han, Nguyen-Hai Nam, Exploration of novel 50 (70 )-substituted-20 -oxospiro [1,3]dioxolane-2,30 -indoline-based N-hydroxypropenamides as histone deacetylase inhibitors and antitumor agents, Arabian Journal of Chemistry, 2017, 10, 465-472.
• Vu Tuan Kien, Le Huy Binh, Phan Hai Phong, Doan Thi Hien, Nguyen Thi Thuy My, Nguyen Hai Nam, Do Thi Thao, Michael Baltas and Tran Khac Vu, Novel Artemisinin-Derived Dimers: Synthesis and Evaluation of Anticancer Activities, Letters in Drug Design & Discovery, 2017, 14 102-111.
• Vu Thi Ha, Vu Tuan Kien, Le Huy Binh, Vu Dinh Tien, Nguyen Thi Thuy My, Nguyen Hai Nam, Michael Baltas, Hyunggu Hahn, Byung Woo Han, Do Thi Thao, Tran Khac Vu, Design, synthesis and biological evaluation of novel hydroxamic acids bearing artemisinin skeleton, Bioorganic Chemistry, 2016, 66, 63-71.
• Le Huy Binh, Nguyen Thi Thuy Van, Vu Tuan Kien, Nguyen Thi Thuy My, Luu Van Chinh,  Nguyen Thi Nga, Hoang Xuan Tien, Do Thi Thao & Tran Khac Vu,  Synthesis and in vitro cytotoxic evaluation of new triazole derivatives based on artemisinin via click chemistry. Med Chem Res, 2016, 25, 738–750.
• Thuy Thu Vu, Hyungrok Kim, Vu Khac Tran, Quang Le Dang, Hoa Thi Nguyen, Hun Kim, In Seon Kim, Gyung Ja Choi, Jin-Cheol Kim, In vitro antibacterial activity of selected medicinal plants traditionally used in Vietnam against human pathogenic bacteria, BMC Complementary and Alternative Medicine, 2015, 16, https://doi.org/10.1186/s12906-016-1007-2.
• Thuan, N.T., Dung, D.T.M., Que, D.N. Tran Khac Vu, Youngsoo Kim. Sang-Bae Han, Nguyen Hai Nam, Synthesis and bioevaluation of new 5-benzylidenethiazolidine-2,4-diones bearing benzenesulfonamide moiety. Med Chem Res, 2015, 24, 3803–3812.
• Tran Thi Lan Huong, Do Thi Mai Dung, Phan Thi Phuong Dung, Phung Thanh Huong, TranKhac Vu, Hyunggu Hahn, ByungWoo Han, Jisung Kim, Minji Pyo, Sang-Bae Han, Nguyen-Hai Nam, Novel 2-oxoindoline-based hydroxamic acids: synthesis, cytotoxicity, and inhibition of histone deacetylation, Tetrahedron Letters, 2015, 56, 6425-6429.
• Van Chinh, Luu; Ngoc Hung, Truong; Thi Nga, Nguyen; Phong, Le; Huu Cuong, Le; Tien Chinh, Vu; Un Kim, Soo; Khac Vu, Tran, New Chalcones Containing 5-Fluorouracil Exhibiting in vitro Anti-Cancer Activity,  Letters in Organic Chemistry, 2015, 12, 251-261.
• Nguyen Van Minh, Nguyen Le Anh, Do Thi Thao and Tran Khac Vu, Triazole-linked Chalcone and Flavone Hybrid Compounds Based on AZT Exhibiting in vitro Anti-Cancer Activity, Letters in Drug Design & Discovery, 2014,3, 297-303.
• Van Chinh, Luu; Ngoc Hung, Truong; Thi Nga, Nguyen; phong, Le; Mai Huong, Le; Thi Hong Ha, Tran; Un Kim, Soo; Khac Vu, Tran, New Chalcones Containing Nucleosides Exhibiting In Vitro Anti-cancer Activities, Letters in Organic Chemistry, 2014, 11, 534-545(12).
• Vu, Tran K.; Patil, Sachin Prakash; Park, Yoo Jin; Thao, Do Thi, Synthesis and In Vitro Cytotoxic Activity Evaluation of Novel Mannich Bases and Modified AZT Derivatives Possessing Mannich Base Moieties via Click Chemistry, Letters in Drug Design & Discovery, 2013, 10, 585-593.
• Bui Trung Hieu, Le Thi Thuy, Vu Thu Thuy, Hoang Xuan Tien, Luu Van Chinh,† Vu Dinh Hoang, and Tran Khac Vu, Design, Synthesis and In Vitro Cytotoxic Activity Evaluation of New Mannich Bases, Bull. Korean Chem. Soc. 2012, 33, 1586-1582.
• Le Thi Thuy, Vu Dinh Hoang and Tran Khac Vu, Design, Synthesis and In Vitro Antimalarial Evaluation of New Quinolinylhydrazone Derivatives, Letters in Drug Design & Discovery, 2012, 9, 163-168.
• Vu Tran Khac, Tuyen Nguyen Van and Sung Tran Van, Synthesis of novel 10-deoxoartemisinins, Bioorganic & Medicinal Chemistry Letters, 2005, 15, 2629–2631.
• Vu Tran Khac, Viet Nguyen Van and Tuyen Nguyen Van, A new route to novel 10-deoxoartemisinins, Tetrahedron Letters, 2005, 46, 4243–4245.