QUÁ TRÌNH ĐÀO TẠO

QUÁ TRÌNH CÔNG TÁC

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HƯỚNG NGHIÊN CỨU

• Nghiên cứu phát triển đầu dò quang học giúp kiểm soát môi trường, vệ sinh an toàn thực phẩm, phát hiện mầm bệnh, các dấu hiệu bệnh ở người, và thiết bị phân tích nhanh
• Nghiên cứu phát triển vật liệu nano hữu cơ phát quang định hướng ứng dụng trong y sinh: hình ảnh sinh học, chẩn đoán bệnh, điều trị ung thư/bệnh truyền nhiễm
• Nghiên cứu phát triển vật liệu phát quang tiên tiến

THAM GIA CÁC ĐỀ TÀI NGHIÊN CỨU

CÁC CÔNG TRÌNH KHOA HỌC

• Không

• Yoon Juyoung, Nguyen Van Nghia, Qi Sujie, Kwon Na Hyun., Preparation of benzo[de]isoquinoloine-1,3-dithiones and photodynamic therapy for inactivating or killing tumor cells., 2020, US Patent.
• Yoon Juyoung, Nguyen Van Nghia, Kwon Na Hyun, Qi Sujie., Boron-complex, photosensitizer comprising same, composition for diagnosing or treating tumor targeting mitochondria, and photodynamic treatment method using composition., 2021, US Patent.
• Yoon Juyoung, Nguyen Van Nghia, Yim Yu Bin., Preparation of tetramethyl BODIPY derivatives for diagnosing or treating tumor., 2021, Korean Patent.
• Yoon Juyoung, Nguyen Van Nghia, Heo Seonye., Preparation of thiocoumarinamine as photosensitizer for diagnosing or treating tumor for targeting mitochondria., 2022, Korean Patent.

• [1]. Van-Nghia Nguyen, Dong Joon Lee, Dianqi Zhang, Jeongsun Ha, Kunemadihalli Mathada Kotraiah Swamy, Rui Wangd*, Hwan Myung Kimc*, Fabiao Yu*, and Juyoung Yoon*. “Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer”. Chem. Mater., 2024. Accepted.
• [2]. Thanh Chung Pham^#, Moonyeon Cho^#, Van-Nghia Nguyen^#, Van Kieu Thuy Nguyen, Gyoungmi Kim, Seongman Lee, Wim Dehaen, Juyoung Yoon, Songyi Lee. “Charge Transfer-Promoted Excited State of a Heavy-Atom-Free Photosensitizer for Efficient Application of Mitochondria-Targeted Fluorescence Imaging and Hypoxia Photodynamic Therapy”. ACS Appl. Mater. Interfaces, 2024, 16, 17, 21699-21708. (^#Equal contribution)
• [3]. Yuan-Yuan Zhao, Heejeong Kim, Van-Nghia Nguyen, Sunbok Jang^*, Won Jun Jang^*, Juyoung Yoon*. “Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy”. Coord. Chem. Rev., 2024, 501, 215560.
• [4]. Dinh Khoi Dang^#, Van-Nghia Nguyen^#, Zeeshan Tahir, Hyunsun Jeong, Sungdo Kim, Hong Nhan Tran, Shinuk Cho, Yun Chang Park, Jong-Seong Bae, Chinh Tam Le*, Juyoung Yoon*, Yong Soo Kim*. “An Efficient Green Approach to Constructing Adenine Sulfate-derived Multicolor Sulfur, Nitrogen Co-doped Carbon Dots and their Bioimaging Applications”. ACS Appl. Mater. Interfaces 2023, 15, 27, 32783-32791. (^#Equal contribution)
• [5]. Van-Nghia Nguyen, Thuy Nguyen Thi Dao, Moonyeon Cho, Hyunsun Jeong, Minh-Tri Nguyen-Le, Yong Shin*, and Juyoung Yoon*. “Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy”. Coord. Chem. Rev., 2023, 479, 215006.
• [6]. Van-Nghia Nguyen, Jeongsun Ha, Hyunsun Jeong, Moonyeon Cho, Gyongmi Kim, Juyoung Yoon*. “Rational Molecular Design of Efficient Heavy‐Atom‐Free Photosensitizers for Cancer Photodynamic Therapy”. ChemPlusChem, 2022, e202200086.
• [7]. Heejeong Kim, Mengyao Yang, Nahyun Kwon, Moonyeon Cho, Jingjing Han, Rui Wang, Sujie Qi, Haidong Li, Van-Nghia Nguyen, Xingshu Li, Hong-Bo Cheng, Juyoung Yoon*. “Recent progress on photodynamic therapy and photothermal therapy”. Bull. Korean Chem. Soc., 2022, 44, 236-255.
• [8]. Moonyeon Cho, Van-Nghia Nguyen*, and Juyoung Yoon*. “Simultaneous detection of hypochlorite and singlet oxygen by a thiocoumarin-based ratiometric fluorescent probe”. ACS Meas. Sci. Au, 2022, 2, 3, 219-223.
• [9]. Van-Nghia Nguyen, Zheng Zhao, Ben Zhong Tang*, and Juyoung Yoon*. “Organic photosensitizers for antimicrobial phototherapy”. Chem. Soc. Rev., 2022, 51, 3324-3340.
• [10]. Thanh Chung Pham^#, Van-nghia Nguyen^#, Yeonghwan Choi, Songyi Lee*, Juyoung Yoon*. “Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy”. Chem. Rev. 2021, 121, 21, 13454-13619. (^#Equal contribution)
• [11]. Van-Nghia Nguyen, Yuxin Yan, Jianzhang Zhao*, and Juyoung Yoon*. “Heavy-Atom-Free Photosensitizers: from Molecular Design to Applications in Photodynamic Therapy of Cancer”. Acc. Chem. Res., 2021, 54, 1, 207-220.
• [12]. Van-Nghia Nguyen, Jeongsun Ha, Chang Woo Koh, Bokyeong Ryu, Gyoungmi Kim, Jae-Hak Park, C-Yoon Kim^*, Sungnam Park^*, and Juyoung Yoon^*. “Access to the Triplet Excited States of Heavy-Atom-Free BODIPY Photosensitizers via Radical Pair Intersystem Crossing for Image-Guided Tumor-Targeted Photodynamic Therapy”. Chem. Mater. 2021, 33, 7889-7896.
• [13]. Van-Nghia Nguyen, Seonye Heo, Chang Woo Koh, Jeongsun Ha, Kim Gyoungmi, Sungnam Park*, and Juyoung Yoon*. “A simple route toward next-generation thiobase-based photosensitizers for cancer theranostics. ACS Sens. 2021, 6, 3462-3467.
• [14]. Van-Nghia Nguyen*, Jeongsun Ha, Moonyeon Cho, Haidong Li, K. M. K. Swamy, and Juyoung Yoon*. “Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis”. Coord. Chem. Rev., 2021. 439, 213936.
• [15]. Haidong Li, Heejeong Kim, Jingjing Han, Van-Nghia Nguyen, Xiaojun Peng*, and Juyoung Yoon*. “Activity-Based Smart AIEgens for Detection, Bioimaging, and Therapeutics: Recent Progress and Outlook”. Aggregate. 2021, e51.
• [16]. Thanh Chung Pham, Seonye Heo, Van-Nghia Nguyen, Myung Won Lee, Juyoung Yoon*, and Songyi Lee*. “A molecular design towards heavy-atom-free photosensitizers based on C=S bond and its dual functions in hypoxia photodynamic cancer therapy and OCl- detection”. ACS Appl. Mater. Interfaces, 2021, 13, 12, 13949-13957.
• [17]. Thanh Chung Pham, Van-Nghia Nguyen, Yeonghwan Choi, Dongwon Kim, Ok-Sang Jung, Dong Joon Lee, Hak Jun Kim, Myung Won Lee, Juyoung Yoon, Hwan Myung Kim, Songyi Lee*. “Hypochlorite-activated fluorescence emission and antibacterial activities of imidazole derivatives for biological applications”. Front Chem. 2021; 9, 713078.
• [18]. Sujie Qi, Nahyun Kwon, Yubin Yim, Van-Nghia Nguyen*, and Juyoung Yoon*. “Fine-tuning the electronic structure of heavy-atom-free BODIPY photosensitizers for fluorescence imaging and mitochondria-targeted photodynamic therapy”. Chem. Sci., 2020, 11, 6479-6484.
• [19]. Van-Nghia Nguyen, Sang Jun Park, Sujie Qi, Jeongsun Ha, Seonye Heo, Yubin Yim, Gain Baek, Chang Su Lim, Hwan Myung Kim*, and Juyoung Yoon*. “Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer”. Chem. Commun., 2020, 56, 11489-11492.
• [20]. Van‐Nghia Nguyen, Yubin Yim, Sangin Kim, Bokyeong Ryu, Dr. K. M. K. Swamy, Gyoungmi Kim, Nahyun Kwon. C‐Yoon Kim, Sungnam Park*, Juyoung Yoon*. “Molecular Design of Highly Efficient Heavy‐Atom‐Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging”. Angew. Chem. Int. Ed. 2020, 59, 8957-8962.
• [21]. Sujie Qi, Sangin Kim, Van-Nghia Nguyen*, Youngmee Kim, Guangle Niu, Gyoungmi Kim, Sung-Jin Kim, Sungnam Park*, and Juyoung Yoon*. “Highly Efficient Aggregation-Induced Red-Emissive Organic Thermally Activated Delayed Fluorescence Materials with Prolonged Fluorescence Lifetime for Time-Resolved Luminescence Bioimaging”. ACS Appl. Mater. Interfaces, 2020, 12, 46, 51293-51301.
• [22]. Van-Nghia Nguyen, Gain Baek, Sujie Qi, Seonye Heo, Yubin Yim, and Juyoung Yoon*. “A Lysosome-Localized Thionaphthalimide as a Potential Heavy-Atom-Free Photosensitizer for Selective Photodynamic Therapy”. Dyes and Pigments, 2020, 177, 108265.
• [23]. Van-Nghia Nguyen, Seonye Heo, Sangin Kim, K. M. K. Swamy, Jeongsun Ha, Sungnam Park,* Juyoung Yoon*. “A thiocoumarin-based turn-on fluorescent probe for hypochlorite detection and its application to live-cell imaging”. Sensors and Actuators B: Chemical, 2020, 317, 128213.
• [24]. Van-Nghia Nguyen, Sujie Qi, Sangin Kim, Nahyun Kwon, Gyoungmi Kim, Yubin Yim, Sungnam Park* and Juyoung Yoon*. “An emerging molecular design approach to heavy-atom-free photosensitizers for enhanced photodynamic therapy under hypoxia”. J. Am. Chem. Soc., 2019, 141, 41, 16243-16248.

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