Personnel information

Full name: Dr. Luong Xuan Huy

Position: Lecturer

Belongs to the unit: Department of Chemical Engineering

Email address: huy.luongxuan@hust.edu.vn

Specialized group: Pharmaceutical, Cosmetic and Pesticide Chemical Engineering.

Scientific background

QUALIFICATIONS

Year Degree Academic Institution
2020 Doctor Dongguk University, Korea
2016 Master Dongguk University, Korea
2014 Pharmacist Hanoi University of Pharmacy, Vietnam

PROFESSIONAL EXPERIENCE

Time Position Organization
2026-now Lecturer Hanoi University of Science and Technology, Vietnam
2024-2026 Research Professor Yeungnam University, Korea.
2020-2026 Lecturer Phenikaa University, Vietnam.

TEACHING RESPONSIBILITIES

Course ID Course name Program
CH4517E Structure-activity relationships ELITECH program of Pharmaceutical chemical engineering
CH5614 Medicinal Chemistry Project Kỹ thuật Hóa học
CH4516E Seminar ELITECH program of Pharmaceutical chemical engineering
CH4502E Research Project ELITECH program of Pharmaceutical chemical engineering

RESEARCH INTERESTS

  • Bioactive peptide discovery and engineering for therapeutic, diagnostic, nutraceutical, and cosmetic applications.
  • Development of stapled oncolytic peptides and peptide-based nanomedicines for cancer immunotherapy.
  • Rational design of ionizable lipids and lipid nanoparticles for mRNA delivery, vaccines, and gene therapy.
  • Molecular dynamics simulations and computational approaches for elucidating structure–activity relationships and guiding drug design.

PROJECTS

Type of project Name of project Role Time frame
NAFOSTED Synthesis and optimization of peptides from coconut water Cocos nucifera with potential to treat antibacterial and antifungal infections Principle investigator 2023-2026  
Phenikaa Group Laboratory-Scale Synthesis of the Commercial Peptides AH-8 and Leuprorelin Acetate Principle investigator 2022-2023  
Phenikaa University Development of a Laboratory-Scale Chemical Synthesis Process for Antimicrobial Peptides Principle investigator 2020-2021  
NAFOSTED Development of Cationic Amphiphilic Antimicrobial Agents Scientific Secretary 2024-2027  
NAFOSTED Synthesis and Evaluation of the Antibacterial and Anticancer Activities of Natural Lasioglossin-III Peptide Derivatives Key Member 2025-2028  
NAFOSTED Peptide-Based Therapy for Prostate Cancer: From In Vitro research to Personalized Treatment Strategies Using Organoid Models Key Member 2025-2028  
NAFOSTED Development of Standardized Soybean-Derived Peptides for the Treatment of Dyslipidemia Key Member 2025-2028  
               
Book and Book chapter
  • Trương Thanh Tùng, Lương Xuân Huy. Liên quan cấu trúc - tác dụng sinh học của thuốc. Giáo trình giảng dạy Đại học, Nhà xuất bản Đại học Quốc gia Hà Nội, 2021.
  • Binh Le Huy, Hai Bui Thi Phuong, Huy Luong Xuan. Advantages and disadvantages of RNA therapeutics (Chương sách). Progress in Molecular Biology and Translational Science 203, 151-164, 2025.
  • Hai Bui Thi Phuong, Thang Nguyen Quoc, Van-Duong Dao, Huy Luong Xuan. Molecular Simulation Approaches to Elucidate the Structure and Antimicrobial Mechanisms of Amphipathic Helical Peptides (Chương sách). Theoretical and Computational Materials Science: Advances and Applications 2025.
Intellectual properties
  • Peptide comprising stabilized polyproline Ⅱ helix, South Korea, 2023.
  • Process for the synthesis and purification of Pentapeptide-3 (Quy trình tổng hợp và tinh chế hợp chất pentapeptit-3), Giải pháp hữu ích Việt Nam, 2025.
All publications
  1. Thang Nguyen Quoc, Hai Bui Thi Phuong, Duc Nguyen Van, Duc Nguyen Minh, Hoang Vu Dinh, Tung Truong Thanh, Huy Luong Xuan. Structure–Function Insights into Anionic and Cationic Undecapeptides: A Combined Modeling and Antibacterial Study. J Membrane Biol 259, 13 (2026). https://doi.org/10.1007/s00232-026-00379-2.
  2. Phuong Dang Khanh, Hai Bui Thi Phuong, Khanh Nguyen Van, Trung Hoang Trinh, Hang Ngo Thu, Mao Can Van, Hiep Tran Tuan, Oanh Nguyen Thi Kieu, Huy Luong Xuan. Co-administration of Antimicrobial Peptides: A Promising Strategy to Broaden Antibacterial Activity and Minimize Hemolysis. International Journal of Peptide Research and Therapeutics 32, 48 (2026). https://doi.org/10.1007/s10989-026-10827-1
  3. Binh Le Huy, Hai Bui, Hai Bui Thi Phuong, Thang Nguyen Quoc, Tiep Nguyen Khac, Ngoc Nguyen Thi Linh, Thi Linh, Khanh Nguyen Van, Binh Nguyen Thi Thanh, Thi Thanh, Hoang Vu Dinh, Huy Luong Xuan. Evolution-driven terminal capping design in antimicrobial peptides revealed by combined experimental and MD simulation approaches. Archives of Microbiology 208, 255 (2026). https://doi.org/10.1007/s00203-026-04782-0.
  4. Phung, M. P.; Thi, T. T.; Phuong, H. B. T.; Do, K. V.; Xuan, H. L. Milk-Derived Bioactive Peptides: Multifunctional Agents in Infant Health and Translational Perspectives for Therapeutic Applications. European Food Research and Technology 2025, 252 (1), 5. https://doi.org/10.1007/s00217-025-04954-0.
  5. Phuong, H. B. T.; Nguyen, T. N.; Thi, H. H.; Huang, L.; Tran, P.-T.; Quoc, T. N.; Dao, V.-D.; Bui, L. M.; Xuan, H. L. Structural Optimization of Cn-AMP1 Enhances Antibacterial and Anticancer Potency With Low Hemolysis. Biopolymers 2026, 117 (1), e70068. https://doi.org/10.1002/bip.70068.
  6. Shrestha, A.; Karmacharya, P.; Shrestha, S.; Mishra, S.; Patil, R. H.; Kim, B.; Luong, H. X.; Ku, S. K.; Kim, J.; Patil, B. R.; Kim, J. O. Combining Sodium Chloride Nanoparticle Osmolarity Spikes with Irinotecan Chemotherapy to Amplify Oxidative Stress in the Treatment of Colorectal Cancer. Colloids and Surfaces B: Biointerfaces 2026, 259, 115294. https://doi.org/10.1016/j.colsurfb.2025.115294.
  7. Nguyen, T.-P.; Phuong, H. B. T.; Thanh, B. N. T.; Giap, H. T.; Xuan, H. L.; Bui, L. M. Antimicrobial and Anti-Virulence Activities of Mastoparan C and Its Derivatives against Methicillin-Resistant Staphylococcus Aureus. Journal of Applied Microbiology 2025, 136 (10), lxaf254. https://doi.org/10.1093/jambio/lxaf254.
  8. Karmacharya, P.; Shrestha, A.; Kim, B.; Luong, H. X.; Kim, J.; Patil, B. R.; Kim, J. O. Fabrication of Poly-L-Histidine-Coated Mesoporous Silica Nanoparticles with Hyaluronic Acid for Targeted Doxorubicin Delivery. Journal of Pharmaceutical Investigation 2025. https://doi.org/10.1007/s40005-025-00773-3.
  9. Ngo Van, H.; Luong Xuan, H.; Le Viet, H.; Phuong, H. B. T.; Do Hai, Y.; Thang, N. Q.; Truong Thanh, T.; Yen, T. V.; Minh, T. N.; Van, L. N.; Ngo Thu, H.; Can Van, M. Indolicidin Derivatives as Potent Dual-Action Antifungal and Antibacterial Agents for the Treatment of Skin Infections: A Comprehensive Study from in Vitro to in Vivo Evaluation. PLOS ONE 2025, 20 (9), e0331796. https://doi.org/10.1371/journal.pone.0331796.
  10. Bui Thi Phuong, H.; Phuong, N.-T.; Bui, L. M.; Pham Thi, H.; Tran, T. T. P.; Nguyen Quoc, T.; Tran, H. T.; Nguyen Hong, M.; Luong Xuan, H. Optimizing Amphipathic Antimicrobial Peptides via Helical Wheel Rotation. ChemMedChem 2025, n/a (n/a), e202500316. https://doi.org/10.1002/cmdc.202500316.
  11. Phuong, H. B. T.; Minh, D. N.; Bui, L. M.; Quoc, T. N.; Thanh, T. T.; Xuan, H. L. Balancing Length and Hydrophobicity in Cationic Amphipathic Peptides: Insights From Biological Analysis and Molecular Simulation. Peptide Science 2025, 117 (5), e70010. https://doi.org/10.1002/pep2.70010.
  12. Nguyen, T. O. O.; Nguyen, B. L.; Patil, B. R.; Le, N. D.; Kim, B.; Jin, S. G.; Choi, H.-G.; Ku, S. K.; Luong, H. X.; Kim, J.; Park, S.-Y.; Kim, J. O. uPAR-Targeted Senolytic Delivery to Enhance Cancer Therapy. Journal of Pharmaceutical Investigation 2025. https://doi.org/10.1007/s40005-025-00757-3.
  13. Bui Thi Phuong, H.; Nguyen, B. L.; Huang, L.; Nguyen, T. O. O.; Le, N. D.; Kim, B.; Patil, B. R.; Nguyen Quoc, T.; Kim, J.; Luong, H. X.; Kim,  and J. O. Developing Potent and Selective Anticancer Therapy through Chemical Approaches and the Combination of Cationic Amphipathic Oncolytic Peptides. Journal of Medicinal Chemistry 2025, 68 (11), 11875–11893. https://doi.org/10.1021/acs.jmedchem.5c00699.
  14. Ngan, H. D.; Huy, B. L.; Uyen, C. L.; Phuong, H. B. T.; Xuan, H. L. Antimicrobial Peptides in Green Coconut Water: From Nutritional Benefits to Multifunctional Applications for Human Health. European Food Research and Technology 2025. https://doi.org/10.1007/s00217-025-04754-6.
  15. Thu, H. N.; Van, H. N.; Phuong, H. B. T.; Duc, T. P.; Van, K. H.; Vu, K. N.; Van, T. N.; Thuy, L. D.; Bui, L. M.; Thanh, T. T.; Xuan, H. L.; Van, M. C. The Importance Role of Central Proline to the Antimicrobial Potency and Selectivity of Indolicidin. Archives of Microbiology 2025, 207 (4), 97. https://doi.org/10.1007/s00203-025-04299-y.
  16. Le Huy, B.; Phuong, H. B. T.; Thanh, B. N. T.; Van, Q. T.; Dinh, H. V.; Xuan, H. L. Influence of Hydrophobicity on the Antimicrobial Activity of Helical Antimicrobial Peptides: A Study Focusing on Three Mastoparans. Molecular Diversity 2024. https://doi.org/10.1007/s11030-024-11046-w.
  17. Phuong, H. B. T.; Ngan, H. D.; Thi, H. P.; Thanh, B. N. T.; Dang, T. T.; Ho, T. N. T.; Thanh, T. T.; Hong, M. N.; Xuan, H. L. Dual Antimicrobial and Anticancer Activity of Membrane-Active Peptide BP52. The Protein Journal 2024, 43 (5), 1025–1034. https://doi.org/10.1007/s10930-024-10231-y.
  18. Tran, G.-H.; Tran, T.-H.; Pham, S. H.; Xuan, H. L.; Dang, T. T. Cyclotides: The next Generation in Biopesticide Development for Eco-Friendly Agriculture. Journal of Peptide Science 2024, 30 (6), e3570. https://doi.org/10.1002/psc.3570.
  19. Tran, D. V. H.; Luong, H. X.; Kim, D.-H.; Lee, B.-J.; Kim, Y.-W. Lysine-Homologue Substitution: Impact on Antimicrobial Activity and Proteolytic Stability of Cationic Stapled Heptapeptides. Bioorganic & Medicinal Chemistry 2024, 106, 117735. https://doi.org/10.1016/j.bmc.2024.117735.
  20. Bui Thi Phuong, H.; Do Hai, Y.; Nguyen Huu, V.; Luong The, A.; Nguyen Hong, M.; Luong Xuan, H. Naturally Occurring and Artificially Designed Antimicrobial Peptides: A Comparative Study of Mastoparan C and BP52. Medicinal Chemistry Research 2024, 33 (5), 735–739. https://doi.org/10.1007/s00044-024-03205-3.
  21. Bui Thi Phuong, H.; Doan Ngan, H.; Le Huy, B.; Vu Dinh, H.; Luong Xuan, H. The Amphipathic Design in Helical Antimicrobial Peptides. ChemMedChem 2024, 19 (7), e202300480. https://doi.org/10.1002/cmdc.202300480.
  22. Thi Phuong, H. B.; Huy, B. L.; Van, K. N.; Thi, N. D.; Thi, T. B.; Thi Hai, Y. N.; Thanh, T. B.; Xuan, H. L.; Thi Thanh, B. N. Reducing Self-Assembly by Increasing Net Charge: Effect on Biological Activity of Mastoparan C. ACS Medicinal Chemistry Letters 2024, 15 (1), 69–75. https://doi.org/10.1021/acsmedchemlett.3c00385.
  23. Hai, B. T. P.; Yen, D. H.; Anh, T. T. K.; Minh, N. H.; Binh, N. T. T.; Huy, L. X.; Hoang, V. D. Synthesis and Biological Comparison of Two Antimicrobial Peptides Originated from the Venom of Vespa Crabro and Polybia Paulista. Vietnam J. Sci. Technol. 2024, 62 (2), 222–232.
  24. Bui Thi Phuong, H.; Le Uyen, C.; Doan Ngan, H.; Luong Xuan, H. Impact of Chemical Modifications on the Antimicrobial and Hemolytic Activity of Helical Amphipathic Peptide Lasioglossin LL-III. Amino Acids 2023, 55 (11), 1531–1544. https://doi.org/10.1007/s00726-023-03326-w.
  25. Phuong, H. B. T.; Tran, V. A.; Ngoc, K. N.; Huu, V. N.; Thu, H. N.; Van, M. C.; Thi, H. P.; Hong, M. N.; Tran, H. T.; Xuan, H. L. Effect of Substituting Glutamine with Lysine on Structural and Biological Properties of Antimicrobial Peptide Polybia-MP1. Amino Acids 2023, 55 (7), 881–890.
  26. Luong, H. X.; Bui, H. T. P.; Tung, T. T. Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides. Journal of Medicinal Chemistry 2022, 65 (4), 3026–3045. https://doi.org/10.1021/acs.jmedchem.1c01744.
  27. Xuan, H. L.; Duc, T. D.; Thuy, A. M.; Chau, P. M.; Tung, T. T. Chemical Approaches in the Development of Natural Nontoxic Peptide Polybia-MP1 as a Potential Dual Antimicrobial and Antitumor Agent. Amino Acids 2021, 53 (6), 843–852.
  28. Luong, H. X.; Ngan, H. D.; Thi Phuong, H. B.; Quoc, T. N.; Tung, T. T. Multiple Roles of Ribosomal Antimicrobial Peptides in Tackling Global Antimicrobial Resistance. Royal Society Open Science 2022, 9 (1), 211583.
  29. Tung, T. T.; Xuan, H. L. “Left-Hand Strategy” for the Design, Synthesis and Discovery of Novel Triazole–Mercaptobenzothiazole Hybrid Compounds as Potent Quorum Sensing Inhibitors and Anti-Biofilm Formation of Pseudomonas Aeruginosa. New Journal of Chemistry 2021, 45 (46), 21631–21637. https://doi.org/10.1039/D1NJ04436B.
  30. Thanh, T. T.; Xuan, H. L.; Quoc, T. N. Benzo[d]Thiazole-2-Thiol Bearing 2-Oxo-2-Substituted-Phenylethan-1-Yl as Potent Selective lasB Quorum Sensing Inhibitors of Gram-Negative Bacteria. RSC Advances 2021, 11 (46), 28797–28808. https://doi.org/10.1039/D1RA03616E.
  31. Quoc, T. N.; Thi, K. D. N.; Dang, T. P.; Xuan, H. L.; Tung, T. T. Comparison between Three Techniques for Determining Glomerular Filtration Rates: 99m: Tc-Diethylene Triamine Penta-Acetic Acid Renography, Double Plasma Sampling Method, and Single Plasma Sampling Method in Vietnamese Patients. Indian Journal of Nuclear Medicine 2021, 36 (3).
  32. Luong, H. X.; Thanh, T. T.; Tran, T. H. Antimicrobial Peptides – Advances in Development of Therapeutic Applications. Life Sciences 2020, 260, 118407. https://doi.org/10.1016/j.lfs.2020.118407.
  33. Luong, H. X.; Kim, Y.-W. Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples. Organic Letters 2020, 22 (20), 7986–7990. https://doi.org/10.1021/acs.orglett.0c02914.
  34. Thanh, T. T.; Quoc, T. N.; Xuan, H. L. Fusaric Acid and Derivatives as Novel Antimicrobial Agents. Medicinal Chemistry Research 2020, 29 (9), 1689–1696.
  35. Tung, T. T.; Huy, L. X. Metal-Free Synthesis of 2-Mercaptobenzothiazoles and 6-(4-Substituted-1H-1, 2, 3-Triazol-1-Yl)-2-Mercaptobenzothiazoles via Microwave-Assisted Synthesis Pathway. Synthetic Communication. 2020, 50 (13), 2007–2014.
  36. Luong, H. X.; Kim, D.-H.; Lee, B.-J.; Kim, Y.-W. Effects of Lysine-to-Arginine Substitution on Antimicrobial Activity of Cationic Stapled Heptapeptides. Archives of Pharmacal Research 2018, 41 (11), 1092–1097. https://doi.org/10.1007/s12272-018-1084-5.
  37. Luong, H. X.; Kim, D.-H.; Lee, B.-J.; Kim, Y.-W. Antimicrobial Activity and Stability of Stapled Helices of Polybia-MP1. Archives of Pharmacal Research 2017, 40 (12), 1414–1419. https://doi.org/10.1007/s12272-017-0963-5.
  38. Luong, H. X.; Kim, D.-H.; Mai, N. T.; Lee, B.-J.; Kim, Y.-W. Mono-Substitution Effects on Antimicrobial Activity of Stapled Heptapeptides. Archives of Pharmacal Research 2017, 40, 713–719.
  39. Luong, H. X.; Kim, D.; Lee, B.; Kim, Y. Antimicrobial and Hemolytic Activity of Stapled Heptapeptide Dimers. Bulletin of the Korean Chemical Society 2016, 37 (8), 1199–1203.
  40. Nguyen, L. T.; Luong, H. X.; Kim, Y.-W. Helix Nucleation via Hydrocarbon Cross-Link Mimicking N-Capping Box. Bulletin of the Korean Chemical Society 2016, 37 (4), 566–570. https://doi.org/10.1002/bkcs.10727.
  41. Dinh, T. T. T.; Kim, D.-H.; Luong, H. X.; Lee, B.-J.; Kim, Y.-W. Antimicrobial Activity of Doubly-Stapled Alanine/Lysine-Based Peptides. Bioorganic & Medicinal Chemistry Letters 2015, 25 (18), 4016–4019. https://doi.org/10.1016/j.bmcl.2015.06.053.

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