Personnel information

Full name: Assoc. Prof. Dr. Le Thanh Ha

Position: Lecturer

Belongs to the unit: Department of Bioengineering

Email address: ha.lethanh@hust.edu.vn

Scientific background

QUALIFICATIONS

Year Degree Education organization
2005 Doctor University of Halle, Germany
1994 Master of Science Hanoi University of Science and Technology, Vietnam
1991 Engineer of Biotechnology Moscow Academy of Food Technology, Russia

PROFESSIONAL EXPERIENCE

Time frame Occupation Organization
2018-now Lecturer, Researcher Hanoi University of Science and Technology, Vietnam
2000-2005 PhD Student, Researcher University of Halle, Germany
1992-1998 Lecturer, Researcher Hanoi University of Science and Technology, Vietnam
1998-1999 Trainer CDG, Germany

TEACHING RESPONSIBILITIES

Course ID Course name Program
BF2701 Introduction to Biotechnology Bioengineering
BF3713 Equipment and Process for Biotechnology Bioengineering
BF4709 Downstream process Bioengineering
BF4727 Project Bioengineering
BF4506 Waste managemnet in Food Industry Food engineering
BF6713 Bioseparation Bioengineering

RESEARCH INTERESTS

  • Microbial enzyme.
  • Application of microorganism and enzyme to shrimp waste treatment.
  • Hydrolysis of chitin, lignocellulose, protein.

PROJECTS

Type of project Name of project Role Time frame
Ministry of Agriculture and Rural development Application of microorganisms and enzymes for value added products from shrimp waste. Principle investigator 2009-2011
Ministry of Science and Technology Biotechnological exploitation of antimicrobial coumpounds from by-products of fishery factories for  meat preservation Participant 2012
Ministry of Education and Training Research on using Aspergillus oryzae and Bacillus subtilis for obtaining bioactive compounds from fermented black bean for supporting diabetes patients. Participant 2012-2013
Ministry of Education and Training Research on procedure of recovery N-acetyl-D-glucosamine using chitinase and hexosaminidase, Principle investigator 2014-2015
Ministry of Trade Production of food and animal feeds from by-products of shrimp processing industry Participant 2016-2017
Ministry of Education and Training Isolation and selection of halophilic lactic acid bacteria Tetragenococcus sp. for using as starter culture to improve the aroma quality of short-term fermented fish sauce. Ministry of Education and Training. Principle investigator 2017-2018
Ministry of Education and Training Study on production of starter culture using halophile aroma-produced bacteria for applying in fish sauce fermentation of trashfish and derived protein from shrimp waste. Principle investigator 2021-2022
International cooperation project Production of lysine for feed supplements from shrimp waste using metabolically engineered Vibrio natriegens (ScampiLys) Principle investigator 2021-2024

Book and Book chapter
  • Son Chu-Ky, Nguyen-Thanh Vu, Quyet-Tien Phi, Tuan Pham Anh, Kim-Anh To, Le-Ha Quan, Tien-Thanh Nguyen, Hong-Nga Luong, Thu-Trang Vu, Tien-Cuong Nguyen, Tuan-Anh Pham, Thanh-Ha Le, Ngoc Tung Quach, Chinh-Nghia Nguyen. Valorization of Agro-Industrial Byproducts. Adding Values to Agro-Industrial Byproducts for the Bioeconomy in Vietnam: CRC Press, Taylor & Francis Group, India, 2023.
Intellectual properties
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Phi Quyet Tien. No 1181 according to 26188/QĐ-SHTT 12/05/2014. Process for production of chitoologosaccharit powder from chitosan.
  • Le Thanh Ha, Nguyen Thi Minh Tu, Nguyen Tien Thanh. Halophile Tetragenococcus halophilus V7-3. No 2670, 2021.
All publications
  • Le Thanh Ha. Effect of initial saccarose concentration, initial pH and inoculum size on fermentation of mulberry juice. Journal of Science and Technology. 1994 (5).
  • Sanden AM, Prytz I, Tubulekas I, Forberg C, Le H, Hektor A, Neubauer P, Pragai Z, Harwood C, Ward A, Picon A, De Mattos JT, Postma P, Farewell A, Nystrom T, Reeh S, Pedersen S, Larsson G. Limiting factors in Escherichia coli fed-batch production of recombinant proteins. Biotechnol Bioeng. 2003 Jan 20;81(2):158-66.
  • Lethanh H, Neubauer P, Hoffmann F. The small heat-shock proteins IbpA and IbpB reduce the stress load of recombinant Escherichia coli and delay degradation of inclusion bodies. : Microb Cell Fact. 2005 Feb 11;4(1):6.
  • Le Thanh H, Hoffmann F. Optimized production of active alpha-glucosidase by recombinant Escherichia coli. Evaluation of processes using in vivo reactivation from inclusion bodies. Biotechnol Prog. 2005 Jul-Aug;21(4):1053-61.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Quan Le Ha. Study on appopriate conditions for chitosanase biosynthesis by Penicillium oxalicum BKH2. Journal of Science and Technology technical universities. 2009 (71), 74-79.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai, Nguyen Thi Hong Diep.  Study on screening of chitosanase-producer strains for chitooligosaccharides production. Journal of Science and Technology technical universities. 2010 (78A), 1-7.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai. Optimization of the conditions for chitosan hydrolysis by Cellluclast 1.5L for chitooligosaccharides production. Journal of Science and Technology. 2010 (48), 359-366.
  • Do Thị Yen, Le Thanh Ha. Study on chitin recovery from shrimp shell using bromelin in pipeapple waste. Journal of Science and Technology. 2010 (48), 367-374
  • Le Thanh Ha, Ngo Thị Bich Ngoc, Nguyen La Anh. Extraction of chitin from shrimp waste by Lactobacillus plantarium NCDN4. Journal of Science and Technology, 49 (1A), tr 7-14, 2011.
  • Le Thanh Ha, Nguyen Thị Huyen Trang. Screening of protease producing Bacillus subtilis DT2 and its application for chitin extraction from shrimp waste. Journal of Science and Technology, 49 (1A), tr 302-308,  2011.
  • Quan Le Ha, Le Thanh Ha, La Quynh Nhu. Alpha-glucosidase inhibitory activity of fermented black bean by using Aspergillus oryzae. Journal of Science and Technology, 49 (1A), 58-64, 2011.
  • Le Thanh Ha, Nguyen Thi Tuyet Mai. Effect of chitosan properties on its antimicrobial activity. Journal of Science and Technology, 49 (6A), 51-58, 2011.
  • Le Thanh Ha, Le Ngoc Hung, Ho Phu Ha. Optimization medium composition for chitisanase production from Penicillium oxalicum BKH2. Journal of Science and Technology, 49 (5B), 484-490, 2011.
  • Le Thanh Ha, Vu Thi Anh Tuyet. Effect of process parameters on chitosan hydrolysis by chitinase from Penicillium oxalicum BKH2. Journal of Science and Technology technical universities, Số 84, tr 141-146, 2012.
  • Le Thanh Ha, Do Thi Hoai Thu. Isolation of chitinase producer strains and conditions for chitinase production. Journal of Science and Technology technical universities, 87A, 36-41, 2012.
  • Ho Phu Ha, Nguyen Hai Yen, Le Thanh Ha. Antagonism towards E. coli of chitosan derived from shrimp waste using biological method. Journal of Science and Technology. 50 (3A), tr. 126-130, 2012.
  • Duong Ngoc Quynh, Le Thanh Ha, Quan Le Ha. Study on recovery of a-glucosidase inhibitor from fermentation broth by Bacillus subtilis M1. Journal of Science and Technology technical universities, 93A, 34-40, 2013.
  • Duong Thi Ngoc Quynh, Dang Thi Huong, Bui Thi Thuong, Le Thanh Ha. Effect of process parameters on chitinase và b-N-acetyl-D-glucosamine production by Penicillium oxalicum 20B. Journal of fisheries science and technology, Special issue, 2013.
  • Le Thanh Ha, Nguyen Thi Ha. Biotechnological process of chitin recovery from shrimp waste using Lactobacillus plantarum NCDN4. Journal of Vietnamese environment. Số 6 (3), 251-255, 2014.
  • Dang Thi Huong, Ha Quang Tung, Le Thanh Ha, Pham Thu Thuy. Effect of pretreatment on hydrolyzing chitin by chitinase from Penicillium oxalicum 20B for. N-acetyl-D-glucosamine production. Journal of Biotechnology, special issue 13(2A), 603 – 609, 2015.
  • Dang Thi Huong, Hoang Nư Le Quyen, Pham Thu Thuy, Le Thanh Ha. Characterization of chitinase fractions obtained by ultrafiltration of culture broth Penicillium oxalicum 20B. Journal of Biotechnology, special issue 13(2A), 611 – 617, 2015.
  • Hoang Nu Le Quyen, Mai Thanh Dat, Le Thanh Ha. Research on recovery and purification of N-acetyl-D-glucosamine produced from chitin by enzymatic method. Journal of Science and Technology 53(4B), 103-110, 2015.
  • Đặng Thi Hường, Phạm Thu Thủy, Lê Thanh Hà. Production of N-acetyl-D-glucosamine by crude chitinase preparation of Penicillium oxalicum 20B. Journal of Science and Technology technical universities 108, 125-129, 2015.
  • Dinh Van Bon, Dang Thi Xuan Tra, Le Thanh Ha. Improvement of chitinase biosynthesis by Penicillium oxalicum 20B for N-acetyl-D-glucosamine production. Journal of Science and Technology 53(4B), 118-125, 2015.
  • Dang Thi Huong, Le Thanh Ha, Pham Thu Thuy. Factors affecting the recovery yield and the purity of N-acetyl glucosamine from chitin hydrolysates. Journal of Science and Technology 54(4A), 23-30, 2016.
  • Hien Thi Nguyen, Xuan Thi Thanh Dao, Lang Thi Nguyen, Nga To Thi, Ha Thanh Le. Isolation, screening and the influence of cultivation factors on cellulase of bacteria isolated from termites gut. Journal of Science and Technology 54(4A), 89-96, 2016.
  • Dao Thi Thanh Xuan, Phi Quyet Tien, Le Thanh Ha. Characterization of cellulase preparation of Bacillus sp. G4 isolated from termites gut. Journal of Science and Technology 54(4A), 115-122, 2016.
  • Nguyen Hoang Anh, Nguyen Van Giang, Le Thanh Ha. Production of N-acetyl-Glucosamine from chitin using recombinant endochitinase and β-hexosamindase. Journal of Vietnam Argricutural Science and Technology 8, 109-114, 2017.
  • To Thi Nga, Đang Xuan Tra, Le Thanh Ha. Isolation of halophilic lactic acid bacteria Tetragenococcus halophilus from Vietnamese fish sauce. Journal of Science and Technology  55(5A), 186-195, 2017.
  • Dang Thi Hương, Le Thanh Ha. Pretreatment for improving the yield of chitin hydrolysis by chitinase from Penicillium oxalicum 20B. Journal of Analytical Science 24 (4B), . tr. 79-85, 2019. ISSN-0868-3224,
  • Nguyen Thanh Hang, Nguyen Minh Thu, Nguyen Ngan Ha, Le Thanh Ha. Isolation, Screening and Identification of protease producing Bacteria from fish sauce. Vietnam Journal of Science and Technology technical universities. 135, 64-69, 2019. ISSN-2354-1083,..
  • Le Thanh Ha, Nguyen Nam Trinh, Le Thi My Chau, Nguyen Thi Minh Tu - Characterization of Tetragenococcus halophilus from Vietnamese fish mash. Vietnam Journal of Science and Technology  57(5), 544-550, 2019.
  • Le Thanh Ha, Le Duy Thang. OPTIMIZATION OF CONDITIONS FOR CAROTENOIDS EXTRACTION FROM SHRIMP WASTE USING ORGANIC SOLVENT. Vietnam Journal of Science and Technology  3B (42-49), 2019.
  • Dao Thi Thanh Xuan, Phi Quyet Tien, Le Thanh Ha. ENZYMATIC SACHARIFICATION OF ALKALINE PRETREATED RICE STRAW BY CELLULASE FROM CELLULOSIMICROBIUM SP. MP1. Vietnam Journal of Science and Technology  58(6A), 244-251, 2020.
  • Ngoc Tung Quach, Hang Thuy Dam, Dinh Man Tran,Thi Hanh Nguyen Vu, Quoc Viet Nguyen, Kim Thoa Nguyen, Quang Huy Nguyen, Cao Bang Phi, Thanh Ha Le, Hoang Ha Chu, Van Thuoc Doan, Douglas J. H. Shyu, Heonjoong Kang, Wen-Jun Li, Quyet Tien Phi. Diversity of microbial community and its metabolic potential for nitrogen and sulfur cycling in sediments of Phu Quoc island, Gulf of Thailand. Brazilian Journal of Microbiology 52(3):1385-1395, 2021.
  • Nguyen Thi-Hanh Vu, Tung Ngoc Quach, Xuan Thi-Thanh Dao, Ha Thanh Le, Chi Phuong Le, Lam Tung Nguyen, Lam Tung Le, Cuong Cao Ngo, Ha Hoang, Ha Hoang Chu, Quyet-Tien Phi. A genomic perspective on the potential of termite-associated Cellulosimicrobium cellulans MP1 as producer of plant biomass-acting enzymes and exopolysaccharides. PeerJ 2021 Jul 28; e11839.
  • Nguyen Trung Thanh, Vu Thi Kieu Oanh, Le Thanh Ha. Factor influencing the survivability of Tetragenococcus halophilus CH6-2 in the spray drying process. Vietnam Journal of Science and Technology. 2023-02-28. DOI: 10.15625/2525-2518/16310
  • Vu Thi Kieu Oanh, Tran Thi Van Anh, Pham Thu Ha, Vi Thi Thanh Hien, Le Thanh Ha. Characterisation of crude chitinase from Vibrio proteolyticus B02 and its application in chitin hydrolysis. Science and Technology Journal of Agriculture and Rural development  371-379, June 2023

 

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