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Group of Biochemistry



1. General introduction

The Biochemistry Group is one of the three specialized engineering groups of the Department of Bioengineering, established on December 11, 2023 under decision 31/QD-SCLS of the Dean of the School of Chemistry and Life Sciences, which is responsible for teaching theoretical and practical modules related to Biochemistry for Bachelor and Engineering Programs Biology, Food Engineering Bachelor's and Engineering Programs, Bioengineering Advanced Programs, Food Engineering Advanced Programs, Biomedical Engineering Bachelor's Programs, and Master's and Doctoral Biotechnology programs. The group currently consists of 7 permanent staff (including 6 doctors, 1 master of science, 1 master of engineering) and 3 collaborators (2 Assoc. PhD, 1 MSc Engineering), from the departments of Microbiology-Biochemistry-Molecular Biology, Biotechnology and the Biotechnology Research and Development Center of the Institute of Biotechnology and Food Technology previously.  The members of the group have 15-25 years of experience in teaching, researching, technology transfer, have been chairing and participating in dozens of research projects at all levels on enzymes, recombinant enzymes and enzymatic techniques applied in industries, environments, developing methods,  tools for rapid analysis of pathogenic microorganisms and toxins based on nucleic acids and proteins, acquisition and application of biologically active substances ..., is the author of many Vietnamese and English textbooks, intellectual property patents. The professional team is committed to bringing the latest knowledge and extensive understanding in the field of Biochemistry to students and the community, contributing to training high-quality human resources for the development and advancement of Bioengineering, Food,  Biomedical in particular and society in general.
 

2. List of officers

Principal officers
  1. PhD. Do Bien Cuong (Team Leader)
Email: cuong.dobien@hust.edu.vn
Office: 201.C4
Phone: +84-24 3868 2452
https://www.researchgate.net/profile/Cuong-Do-16
 
  1. PhD. Le Quang Hoa
Email: hoa.lequang@hust.edu.vn
Offices: 306–B1
Phone: +84-24 36231 457

 
  1. PhD. Nguyen Tien Thanh
Email: thanh.nguyentien@hust.edu.vn
Offices: 305–B1
Phone: +84-24 36231457/+84943459843
https://www.researchgate.net/profile/Tien-Thanh-Nguyen-2
  1. PhD. Le Tuan
Email: tuan.le@hust.edu.vn
Offices: 208–C4
https://www.researchgate.net/profile/Tuan-Le-138
  1. MSc. Le Thi Lan Chi
Email: chi.lethilan@hust.edu.vn
Offices: 305–B1
Phone: +84-24 36231457/+84943459843
  1. MSc. Le Thi Huyen
Email: huyen.lethi@hust.edu.vn
Office: 201b-C4
Phone: +84-24 3868 2452
 
  1. PhD. Phung Thi Thuy
Email: thuy.phungthi@hust.edu.vn
Office: 201b-C4
Phone: +84-24 3868 2452
 


Participating officers
  1. Assoc. Prof. Pham Tuan Anh
  2. Assoc. Prof. Truong Quoc Phong
  3. MSc. Pham Thi Quynh
Leading the professional team/Department of Biochemistry through the periods:
  • Assoc. Prof.Pham Quoc Thang
  • Prof.NGUT Le Van Huong
  • Assoc. Prof. Le Ngoc Tu 
  • PhD. Nguyen Thi Quynh Anh
  • Prof. Dang Thi Thu
  • Assoc. Prof. To Kim Anh
  • Assoc. Prof. Nguyen Thi Xuan Sam
      
Biochemistry officers on the occasion of the 50th anniversary of Hanoi University of Science and Technology

3. Research directions

Currently, our research topics in Biochemistry focus on the main directions:
  • Enzymatics, recombinant enzymes and applied enzymatic engineering in industries and health sciences: this research direction focuses mainly on the acquisition, separation, purification, stabilization of enzymatic preparations and exploitation of the applicability of enzymes of natural origin,  recombinant or immobilized enzymes. Enzymes that have been studied include amylase, beta-glucosidase, beta-galactosidase, acetylcholinesterase, mannanase, xylanase, cellulase, lignin peroxidase, tyrosinase, laccase, chitosanase, nattokinase...
  • Development of methods and tools for the analysis of pathogenic microorganisms, toxins in the fields of medicine, food, animal husbandry based on nucleic acids and based on proteins, enzymes. 
  • Bioactive substances: focuses on the acquisition and exploitation of substances with antioxidant, anti-cancer cell activity, antimicrobial resistance, enzyme suppression, and prebiotic activity.
  • Synthetic biology.

4. Typical scientific topics of members

  • 2023-2024: Research on technology to create organic magnesium complexes from yeast after brewing for application in food and animal husbandry. B2023-BKA-17. Ministry of Education and Training.
  • 2020-2021: Research on obtaining tyrosinase inhibitors from soybean residues and initially applying them in preserving fresh mushrooms after harvest. Hanoi University of Science and Technology.
  • 2019-2020: Research on the application of protein-rich rice wine residues to some food products. Hanoi University of Science and Technology
  • 2014-2017: Research and development of methods and tools for rapid analysis of pathogenic microorganisms and toxins in aquatic products (Vietnam-Italy Protocol), Ministry of Science and Technology
  • 2014-2016: Complete the technological process of manufacturing kit to quickly detect organic phosphorus toxins, carbamates in agricultural products. Pilot production project- Ministry of Education and Training.
  • 2013-2016: Research and development of Norovirus rapid detection kit in krill and non-heated processed foods based on RT-LAMP technique, Ministry of Education and Training
  • 2014 -2015. Research on production technology of Pectic oligosaccharide (POS) by enzyme, applied in functional food processing. Ministry of Industry and Trade
  • 2012-2014: Fixation of recombinant β-galactosidase from Lactobacillus reuteri L103 expression in Lactobacillus plantarum using chitin-binding module on chitin material, application for galacto-oligosaccharide production from lactose (Nafosted), Ministry of Science and Technology
  • 2013: Research and survey on methods to recover starch-accumulating microalgae applied to biofuel production, Hanoi University of Science and Technology
  • 2010-2011: Research on technological process of production of probiotic beverages and green tea polyphenols. Department of Science and Technology HN.
  • 2009-2010: Research on manufacturing and application of macroarray DNA for simultaneous rapid detection analysis of tubercle bacillus and multidrug-resistant tubercle bacillus in Hanoi, Hanoi Department of Science and Technology
  • 2009-2010: Research on creating recombinant enzyme that hydrolyzes lignocellulose for fuel alcohol production. Branch Project Leader, Ministry of Science and Technology.
  • 2009-2010: Evaluation of prebiotic properties of mannooligosaccharide preparations produced from copra residues by biological methods. Ministry of Education and Training
 

NCM staff in the field and test results of mannooligosaccharide prebiotic from copra residues added to white shrimp feed (Do Son, Hai Phong, 2013).
 

Dr. Le Quang Hoa and the nCoV kit product ( Certificate of Merit from the Minister of Education and Training for the research work on prevention and control of the COVID-19 epidemic, decision: 1608/QD-BGDĐT dated 18/06/2020, and honored in the Vietnam Golden Book of Innovation 2020 for typical scientific and technological innovative works and solutions,  fight the COVID-19 epidemic, . Decision number: 490/QD-MTTW-BTT dated 20/08/2020; Vietnam Fatherland Front)
    1. Patents, useful solutions
  • The manufacturing process of the preparation contains Lactoferrin from the recombinant strain of Pichia pastoris KM71-3. Utility Solutions Patent No. 3343, National Office of Intellectual Property, 08/2023.
  • The process of bleaching hardwood pulp after cooking with a recombinant enzyme preparation and bleach, Patent Useful Solution No. 2-2011-00135
  • Method of making swine serum acetylcholinesterase Kit for rapid detection of pesticide residues. Patent Utility Solutions No. 771: National Office of Intellectual Property. 01/06/2009.
  1. Published books
  • Tien-Thanh Nguyen, Tuan-Anh Pham, Lan-Huong Nguyen, Tuan Le, Son Chu-Ky. Microbial exopolysaccharides for food application, in book: Microbial Exopolysaccharides, editorShashi Kant Bhatia,Parmjit Singh Panesar,Sanjeet Mehariya. CRC Press, 2024,
  • Tien-Thanh Nguyen, Phu Ha Ho, Viet-Phu Tu, Le-Ha Quan and Son Chu-Ky. Chapter 12.1. Application and Perspectives in Different World Regions. Part 12. Market trends, prospectives, sustainable development, and R&D perspectives. Gases in Agro-food Processes. ISBN: 9780128124659, pp: 31-35.
  • Phu Ha Ho, Tuan-Anh Pham, Quoc Phong Truong, Lan-Huong Nguyen, Tien-Thanh Nguyen, Hang-Thuy Dam, Chinh Nghia Nguyen, Ha-Anh Nguyen, Quyet-Tien Phi, Hoang Anh Nguyen, Son Chu-Ky. Isolation, Identification and Characterization of Beneficial Microorganisms from Traditional Fermented Foods in "Probiotics, Prebiotics and Synbiotics: Technological Advancements Towards Safety and Industrial Applications" John Wiley & Sons 2022
  • Son Chu-Ky, Nguyen-Thanh Vu, Quyet-Tien Phi, Tuan Pham Anh, Kim-Anh To, Le-Ha Quan, Tien-Thanh Nguyen, Hong-Nga Luong, Thu-Trang Vu, Tien-Cuong Nguyen, Tuan-Anh Pham, Thanh-Ha Le, Ngoc Tung Quach, Chinh Nghia Nguyen. Adding Values to Agro-Industrial Byproducts for the Bioeconomy in Vietnam. CRC press – Taylor and Francis Group, 2022
  • Le Ngoc Tu (Ed.). Industrial Biochemistry Textbook.  Science and Technology Publishing House. 2020
  • Do Bien Cuong, Hoang Quoc Tuan. Enzymatic engineering, in the book: Food Inspection and Traceability. Editor: Nguyen Thi Minh Tu. Polytechnic Publishing, 2016.
  • Dang Thi Thu (ed.). Enzymatic technology.  Science and Technology Publishing House. 2013.
  • Dang Thi Thu (ed.). Biochemical Technology. Science and Technology Publishing House. 2009
  • Le Ngoc Tu (ed.). Toxicology and Food Safety. Science and Technology Publishing House. 2006.
  • Nguyen Thi Hien (ed.). Malt and Beer Science and Technology. Science and Technology Publishing House, 2004
  • Dang Thi Thu and Le Ngoc Tu (co-editors). Cells and biological processes. Science and Technology Publishing House. 2002.
  • Le Ngoc Tu (ed.). Food Chemistry. Science and Technology Publishing House, 1999.
  • Le Ngoc Tu (ed.). Industrial Biochemistry. Science and Technology Publishing House. 1997.
  • Dang Thi Thu (ed.). Biochemistry experiments. Editor: Dang Thi Thu. Hanoi University of Science and Technology. 1997.

7. Contact
Biochemistry Specialization Group
Room 201-C4, Hanoi University of Science and Technology
No. 1, Dai Co Viet Street, Hai Ba Trung District, Hanoi
Fax: 04 3868 2470.

 
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